Localized Amyloidosis

Amyloid deposits in a particular tissue or organ are the exclusive feature of localized amyloidosis, an uncommon form of the disease that is frequently brought on by abnormal protein synthesis.

Under a microscope, deposits found in the afflicted tissue resemble other types of amyloidosis.

Varies based on the specific type of localized amyloidosis, such as brain, pancreas cutaneous (skin), laryngeal (throat), or ocular (eye) involvement.

Symptoms depend on the affected organ and can range from Alzheimer's disease (ß2 amyloid protein), type II diabetes mellitus (Islet amyloid polypeptide), skin lesions (AL cutaneous amyloidosis) to voice changes ( AL laryngeal amyloidosis) or visual disturbances ( AL ocular amyloidosis).